Academic Lead: Dr. Hreinn Stefánsson, deCODE Genetics Inc., Iceland
EFPIA Lead: Dr. Michael Didriksen, H. Lundbeck A/S, Denmark
While in principle the idea of looking at genetic variants as basis of disease or response is straightforward – in practice this has not been achieved in psychiatry. A major hurdle has been that previous efforts have usually involved single groups, with small samples, using restricted ‘candidate-gene’ approaches. By bringing together deCODE and its unmatched datasets of population-based genetic data, and EFPIA with their collectively unmatched clinical samples we have a unique opportunity to go beyond the state-of-the-art. Thus, deCODE will provide variants associated with psychiatric disorders and their expression profiles whereas EFPIA will amplify these findings by providing drug response data and expression profiles before and after treatment for selected patients based on their CNV status. The final outcome of the collaboration is greater than the sum of its parts since neither deCODE nor EFPIA alone can carry out the proposed work.