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IMI | The Innovative Medicines Initiative
EFPIA | European Federation of Pharmaceutical Industries and Associations

Acknowledgement

Publications and other dissemination activities have to include the following acknowledgement:

NEWMEDS - The research leading to these results has received support from the Innovative Medicines Initiative Joint Undertaking under grant agreement n° 115008 of which resources are composed of EFPIA in-kind contribution and financial contribution from the European Union's Seventh Framework Programme (FP7/2007-2013).

Publications

Title: Application of cross-species PET imaging to assess neurotransmitter release in brain
Author: S. Finnema et al.
Journal: Psychopharmacology (Berl)
Link: PubMed_Link

Title: Sensitivity of [11C]ORM-13070 to increased extracellular noradrenaline in the CNS - a PET study in human subjects
Author: J. Lehto et al.
Journal: Psychopharmacology (Berl)
Link: PubMed_Link

Title: Negative symptoms in schizophrenia--the remarkable impact of inclusion definitions in clinical trials and their consequences
Author: J. Rabinowitz et al.
Journal: Schizophr Res.
Link: PubMed_Link

Title: Combining efficacy and completion rates with no data imputation: a composite approach with greater sensitivity for the statistical evaluation of active comparisons in antipsychotic Trials
Author: J. Rabinowitz et al.
Journal: Eur Neuropsychopharmacol
Link: PubMed_Link

Title: Determinants of antipsychotic response in schizophrenia: implications for practice and future clinical trials
Author: J. Rabinowitz et al.
Journal: J Clin Psychiatry
Link: PubMed_Link

Title: An inflammatory biomarker as a differential predictor of outcome of depression treatment with escitalopram and nortriptyline
Author: R. Uher et al.
Journal: Am J Psychiatry
Link: PubMed_Link

Title: Genetic susceptibility for bipolar disorder and response to antidepressants in major depressive disorder
Author: K. E. Tansey et al.
Journal: Am J Med Genet B Neuropsychiatr Genet
Link: PubMed_Link

Title: Copy number variants and therapeutic response to antidepressant medication in major depressive disorder
Author: K. E. Tansey et al.
Journal: Pharmacogenomics J.
Link: PubMed_Link

Title: DNA methylation in interleukin-11 predicts clinical response to antidepressants in GENDEP
Author: T. R. Powell et al.
Journal: Transl Psychiatry
Link: PubMed_Link

Title: The Adult Reading History Questionnaire (ARHQ) in Icelandic: Psychometric Properties and Factor Structure
Author: G. Bjornsdottir
Journal: J. Learn Disabil
Link: PubMed_Link

Title: CNVs conferring risk of autism or schizophrenia affect cognition in controls
Author: H. Stefansson et al.
Journal: Nature
Link: PubMed_Link

Title: A Spatiotemporal Profile of In Vivo Cerebral Blood Flow Changes Following Intranasal Oxytocin in Humans
Author: Y. Paloyelis et al.
Journal: Biol Psychiatry
Link: PubMed_Link

Title: Predicting progression of Alzheimer's disease using ordinal regression
Author: O. M. Doyle et al.
Journal: PLoS One
Link: PubMed_Link

Title: Brain shaving: adaptive detection for brain PET data
Author: E. Grecchi et al.
Journal: Phys Med Biol.
Link: PubMed_Link

Title: Bayesian multi-task learning for decoding multi-subject neuroimaging data
Author: A. F. Marquand et al.
Journal: Neuroimage
Link: PubMed_Link

Title: CNVs conferring risk of autism or schizophrenia affect cognition in controls
Author: H. Stefansson et al.
Journal: Nature
Link: PubMed_Link

Title: Multivariate decoding of brain images using ordinal regression
Author: O. M. Doyle et al.
Journal: Neuroimage
Link: PubMed_Link

Title: Validation of 11C-ORM-13070 as a PET tracer for a2C-adrenoceptors in the human brain
Author: J. Lehto et al.
Journal: Synapse
Link: PubMed_Link

Title: Test-retest reliability of 11C-ORM-13070 in PET imaging of a2C-adrenoceptors in vivo in the human brain
Author: J. Lehto et al.
Journal: Eur J Nucl Med Mol Imaging
Link: PubMed_Link

Title: Amphetamine decreases a2C-adrenoceptor binding of [11C]ORM-13070 – A PET study in the primate brain
Author: S. J. Finnema et al.
Journal: Int J Neuropsychopharmacol
Link: PubMed_Link

Title: C-ORM-13070, a novel PET ligand for brain a2C-adrenoceptors: radiometabolism, plasma pharmacokinetics, whole-body distribution and radiation dosimetry in healthy men
Author: P. Luoto et al.
Journal: Eur J Nucl Med Mol Imaging
Link: PubMed_Link

Title: Reduced 5-HT1B receptor binding in the dorsal brain stem after cognitive behavioural therapy of major depressive disorder
Author: M. Tiger et al.
Journal: Psychiatry Res
Link: PubMed_Link

Title: A PET tracer for brain a2C-adrenoceptors, [11C]ORM-13070: radiosynthesis and preclinical evaluation in rats and knock-out mice
Author: E. Arponen et al.
Journal: J Nucl Med
Link: PubMed_Link

Title: Anti-correlated cortical networks of intrinsic connectivity in the rat brain
Author: A. J. Schwarz et al.
Journal: Brain Connect
Link: PubMed_Link

Title: Haloperidol modulates midbrain-prefrontal functional connectivity in the rat brain.
Author: N. Gass et al.
Journal: Eur Neuropsychopharmacol
Link: PubMed_Link

Title: Simultaneous EEG and fMRI reveals a causally connected subcortical-cortical network during reward anticipation.
Author: M. Plichta et al.
Journal: J Neurosci
Link: PubMed_Link

Title: Amygdala habituation: a reliable fMRI phenotype.
Author: M. Plichta et al.
Journal: Neuroimage
Link: PubMed_Link

Title: Functionally altered neurocircuits in a rat model of treatment-resistant depression show prominent role of the habenula.
Author: N. Gass et al.
Journal: Eur Neuropsychopharmacol
Link: PubMed_Link

Title: Sub-anesthetic ketamine modulates intrinsic BOLD connectivity within the hippocampal-prefrontal circuit in the rat.
Author: N. Gass et al.
Journal: Neuropsychopharmacology
Link: PubMed_Link

Title: Modafinil combined with cognitive training: Pharmacological augmentation of cognitive training in schizophrenia
Author: P. Michalopoulou et al.
Journal: Eur Neuropsychopharmacol
Link: PubMed_Link

Title: Treating impaired cognition in schizophrenia: the case for combining cognitive-enhancing drugs with cognitive remediation
Author: P. Michalopoulou et al.
Journal: Eur Neuropsychopharmacol
Link: PubMed_Link

Title: Modafinil combined with cognitive training is associated with improved learning in healthy volunteers - A randomised controlled Trial
Author: J. Gilleen et al.
Journal:
Eur Neuropsychopharmacol
Link: PubMed_Link

Title: A touch-screen based paired-associates learning (PAL) task for the rat may provide a translatable pharmacological model of human cognitive impairment.
Author: J. C. Talpos et al.
Journal: Pharmacol Biochem Behav
Link: PubMed_Link

Title: PCP-induced deficits in murine nest building activity: employment of an ethological rodent behavior to mimic negative-like symptoms of schizophrenia
Author: C.S. Pedersen et al.
Journal:
Behav Brain Res
Link: PubMed_Link

Title: Re-evaluating the PCP challenge as a pre-clinical model of impaired cognitive flexibility in schizophrenia
Author: L. Fellini et al.
Journal: Eur Neuropsychopharmacol.
Link: PubMed_Link

Title: Alterations in spatial memory and anxiety in the MAM E17 rat model of hippocampal pathology in schizophrenia
Author: F. Gastambide et al.
Journal: Psychopharmacology (Berl)
Link: PubMed_Link

Title: The hippocampal to prefrontal cortex circuit in mice: a promising electrophysiological signature in models for psychiatric disorders
Author: A. Tripathi et al. 
Journal: Brain Struct Funct
Link: PubMed_Link

Title: Phencyclidine inhibits the activity of thalamic reticular gamma-aminobutyric acidergic neurons in rat brain
Author: E. Troyano-Rodriguez
Journal: Biol Psychiatry
Link: PubMed_Link

Title: The natural hallucinogen 5-MeO-DMT, component of Ayahuasca, disrupts cortical function in rats: reversal by antipsychotic drugs
Author: M.S. Riga
Journal: Int J Neuropsychopharmacol.
Link: PubMed_Link

Title: Blockade of MK-801-Induced Heat Shock Protein 72/73 in Rat Brain by Antipsychotic and Monoaminergic Agents Targeting D2, 5-HT1A, 5-HT2A and a1-Adrenergic Receptors.
Author: T. Romón et al.
Journal: CNS Neurol. Disord. Drug Targets
Link: PubMed_Link

Title: Novel therapeutic strategies in major depression: focus on RNAi and ketamine
Author: A. Bortolozzi et al.
Journal: Curr Pharm Des
Link: PubMed_Link

Title: Disruption of thalamocortical activity in schizophrenia models: relevance to antipsychotic drug action.
Author: P. Celada et al.
Journal: Int J Neuropsychopharamcol.
Link: PubMed_Link

Title: Developments in the field of antidepressants, where do we go now?
Author: F. Artigas
Journal: Eur Neuropsychopharmacol.
Link:
PubMed_Link

Title: Determinants of antipsychotic response in schizophrenia: implications for practice and future clinical Trials
Author: J. Rabinowitz et al.
Journal: J Clin Psychiatry
Link: PubMed_Link

Title: The modelling challenge
Journal: Nature (Editorial based on interviews with several NEWMEDS scientists)
Link: Download_Editorial_Nature

Title: Negative symptoms in schizophrenia--the remarkable impact of inclusion definitions in clinical trials and their consequences
Author: J. Rabinowitz et al.
Journal: Schizophr Res
Link: PubMed_Link

Title: Combining efficacy and completion rates with no data imputation: A composite approach with greater sensitivity for the statistical evaluation of active comparisons in antipsychotic trials
Author: J. Rabinowitz et al.
Journal: Eur Neuropsychopharmacol.
Link: PubMed_Link

Title: Copy Number Variants and Therapeutic Response to Antidepressant Medication in Major Depressive Disorder
Author: K. E. Tansey et al.
Journal: Pharmacogenomics J
Link: PubMed_Link

Title: Genetic susceptibility for bipolar disorder and response to antidepressants in major depressive disorder
Author: K. E. Tansey et al.
Journal: Am J Med Genet B Neuropsychiatr Genet
Link: PubMed_Link

Title: CNVs conferring risk of autism or schizophrenia affect cognition in controls
Author: H. Stefánsson et al.
Journal: Nature
Link: PubMed_Link

Title: Blockade of MK-801-Induced Heat Shock Protein 72/73 in Rat Brain by Antipsychotic and Monoaminergic Agents Targeting D2, 5-HT1A, 5-HT2A and a1-Adrenergic Receptors
Author: T. Romón et al.
Journal:
CNS Neurol Disord Drug Targets
Link: PubMed_Link

Title: Novel therapeutic strategies in major depression: focus on RNAi and ketamine
Author: A. Bortolozzi et al.
Journal: Curr Pharm Des
Link: PubMed_Link

Title: Issues and perspectives in designing clinical trials for negative symptoms
Author: S. R. Marder et al.
Journal: Schizophr Res
Link: PubMed_Link

Title: Clinical trials of negative symptoms – the remarkable impact of inclusion definitions and their consequences
Author: J. Rabinowitz et al.
Journal:
Schizophr Res
Link: PubMed_Link

Title: Whole-exome sequencing identifies a polymorphism in the BMP5 gene associated with SSRI treatment response in major Depression
Author: A. Tammiste et al.
Journal:
J Psychopharmacol
Link: PubMed_Link

Title: DNA methylation in interleukin-11 predicts clinical response to antidepressants in GENDEP
Author: T. R. Powell et al.
Journal: Transl Psychiatry
Link: PubMed_Link

Title: A genome-wide association study of a sustained pattern of antidepressant response
Author: A. M. Hunter et al.
Journal: J Psychiatr Res
Link: PubMed_Link

Title: Contribution of common genetic variants to antidepressant response
Author: K. E. Tansey et al.
Journal: Biol Psychiatry
Link: PubMed_Link

Title: Genetic predictors of response to serotonergic and noradrenergic antidepressants in major depressive disorder: a genome-wide analysis of individual-level data and a meta-analysis
Author: K. E. Tansey et al.
Journal:
PLoS Med
Link: PubMed_Link

Title: CNVs conferring risk of schizophrenia affect cognition and brain structure in control carriers
Author: H. Stefánsson et al.
Journal: Nature
Link: PubMed_Link

Title: Bridging paradigms: hybrid mechanistic-discriminative predictive models
Author: O. M Doyle et al.
Journal: IEEE Trans Biomed Eng
Link: PubMed_Link

Title: Quantifying the attenuation of the ketamine pharmacological magnetic resonance imaging response in humans: a validation using antipsychotic and glutamatergic agents
Author: O. M. Doyle et al.
Journal: J Pharmacol Exp Ther
Link: PubMed_Link

Title: Multivariate decoding of brain images using ordinal regression
Author: O. M. Doyle et al.
Journal: Neuroimage
Link: PubMed_Link

Title: Test-retest reliability of [11C]AZ10419369 binding to 5-HT1B receptors in human brain
Author: M. Nord et al.
Journal: Eur J Nucl Med Mol Imaging
Link: PubMed_Link

Title: Sub-anesthetic ketamine modulates intrinsic BOLD connectivity within the hippocampal-prefrontal circuit in the rat
Author: N. Gass et al.
Journal: Neuropsychopharmacology
Link: PubMed_Link

Title: Anti-correlated cortical networks of intrinsic connectivity in the rat brain
Author: A. J. Schwarz et al.
Journal: Brain Connect
Link: PubMed_Link

Title: Simultaneous EEG and fMRI reveals a causally connected subcortical-cortical network during reward anticipation
Author: M. Plichta et al.
Journal: J Neurosci
Link: PubMed_Link

Title: The low-frequency BOLD functional connectivity signature of the hippocampal-prefrontal network in the rat brain
Author: A. J. Schwarz et al.
Journal: Neuroscience
Link: PubMed_Link

Title: Consideration of species differences in developing novel molecules as cognition enhancers
Author: J. W. Young et al.
Journal: Neurosci Biobehav Rev
Link: PubMed_Link

Title: Dissociation between memory retention across a delay and pattern separation following medial prefrontal cortex lesions in the touchscreen TUNL Task
Author: K. A. L. McAllister et al.
Journal: Neurobiol Learn Mem
Link: PubMed_Link

Title: The touchscreen operant platform for assessing executive function in rats and mice
Author: A. E. Horner et al.
Journal: Nature Protocols
Link: PubMed_Link

Title: The touchscreen operant platform for assessing executive function in rats and mice
Author: A. Mar et al.
Journal: Nature Protocols
Link: PubMed_Link

Title: Testing long-term memory in animal models of schizophrenia: suggestions from CNTRICS
Author: T. J. Bussey et al.
Journal: Neurosci Biobehav Rev
Link: PubMed_Link

Title: Measuring reinforcement learning and motivation constructs in experimental animals: relevance to the negative symptoms of schizophrenia
Author: A. Markou et al.
Journal: Neurosci Biobehav Rev
Link: PubMed_Link

Title: Negative symptoms in schizophrenia – the remarkable impact of inclusion definitions in clinical trials and their consequences
Author: J. Rabinowitz et al.
Journal: Schizophrenia Research
Link: PubMed_Link

Title: A Mouse Model that Recapitulates Cardinal Features of the 15q13.3 Microdeletion Syndrome Including Schizophrenia- and Epilepsy-Related Alterations
Author: K. Fejgin et al.
Journal: Science Direct
Link: PubMed_Link

Title: Multivariate decoding of brain images using ordinal Regression
Author: O. Doyle et al.
Journal: Neuroimage
Link: PubMed_Link

Title: Disruption of thalamocortical activity in schizophrenia models: Relevance to antipsychotic drug Action
Author: P. Celada et al.
Journal: Int J Neuropsychopharamcol
Link: PubMed_Link

Title: Developments in the field of antidepressants, where do we go now?
Author: F. Artigas
Journal: Eur Neuropsychopharmacol
Link: PubMed_Link

Title: Future directions for serotonin and antidepressants
Author: F. Artigas
Journal: ACS Chem Neurosci
Link: PubMed_Link

Title: Negative symptoms in schizophrenia – the remarkable impact of inclusion definitions in clinical trials and their consequences
Author: J. Rabinowitz et al.
Journal: Schizophr Res
Link: PubMed_Link

Title: Haloperidol modulates midbrain-prefrontal functional connectivity in the rat brain
Author: N. Gass et al.
Journal: Euro Neuropsychopharmacol
Link: PubMed_Link

 

 

Title: Improving success of novel therapeutics for cognitive aspects of psychiatric disease: a bridge too far?
Author: F. Gastambide et al.
Journal: Expert Rev Clin Pharmacol.
Link: PubMed_Link

Title: Effect of a single dose of escitalopram on serotonin concentration in the non-human and human primate brain
Author: M. Nord et al.
Journal: International Journal of Neuropsychopharmacology
Link: PubMed_Link

Title: Expression of a1adrenergic receptors in rat prefrontal cortex: cellular colocalization with 5HT2A receptors
Author: N. Santana et al.
Journal: International Journal of Neuropsychopharmacology
Link: PubMed_Link

Title: Behavioral and molecular biomarkers in translational animal models for neuropsychiatric disorders
Author: Z. Sarnyai
Journal: Int Rev Neurobiol
Link:PubMed_Link

Title: Molecular validation of the acute phencyclidine rat model for schizophrenia: identification of translational changes in energy metabolism and neurotransmission
Author: A. Ernst et al.
Journal: J Proteome Res
Link: PubMed_Link

Title: Analysis of the rat hypothalamus proteome by data-independent label-free LC-MS/MS
Author: V. Stelzhammer et al.
Journal: Proteomics
Link: PubMed_Link

Title: Proteomic analysis of the maternal protein restriction rat model for schizophrenia: Identification of translational changes in hormonal signaling pathways and glutamate neurotransmission
Author: P. C. Guest et al.
Journal: Proteomics
Link: PubMed_Link

Title: The application of selective reaction monitoring confirms dysregulation of glycolysis in a preclinical model of schizophrenia
Author: D. Martins-de-Souza et al.
Journal: BMC Res Notes 
Link: PubMed_Link

Title: Common variant at 16p11.2 conferring risk of psychosis
Author: S. Steinberg et al.
Journal: Molecular Psychiatry
Link: PubMed_Link

Title: Selective Remediation of Reversal Learning Deficits in the Neurodevelopmental MAM Model of Schizophrenia by a Novel mGlu5 Positive Allosteric Modulator
Author: F. Gastambide et al.
Journal: Neuropsychopharmacology
Link: PubMed_Link

Title: CNTRICS final animal model task selection: Control of attention
Author: C. Lustig et al.
Journal: Neuroscience and Biobehavioral Reviews
Link: PubMed_Link

Title: Measuring the construct of executive control in schizophrenia: Defining and validating translational animal paradigms for discovery research
Author: G. Gilmour et al.
Journal: Neuroscience and Biobehavioral Reviews
Link: PubMed_Link

Title: Genetic Predictors of Response to Serotonergic and Noradrenergic Antidepressants in Major Depressive Disorder: A Genome-Wide Analysis of Individual-Level Data and Meta-Analysis
Author: K. E. Tansey et al.
Journal: PLOS Medicine
Link: PubMed_Link

Title: Serotonin receptors involved in antidepressant effects
Author: F. Artigas
Journal: Pharmacology & Therapeutics
Link: PubMed_Link

Title: The application of selective reaction monitoring confirms dysregulation of glycolysis in a preclinical model of schizophrenia
Author: D. Martins-de-Souza et al.
Journal: BMC Research Notes
Link: PubMed_Link

Title: Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus
Author: S. Jacquemont et al.
Journal: Nature
Link: PubMed_Link

Title: De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia
Author: G. Kirov et al.
Journal: Molecular Psychiatry
Link: PubMed_Link

Title: Synaptic transmission changes in fear memory circuits underlie key features of an animal model of schizophrenia
Author: M. Pollard et al.
Journal: Behavioural Brain Research
Link: PubMed_Link

Title: Translating potential biomarker candidates for schizophrenia and depression to animal models of psychiatric disorders
Author: W. Kluge et al.
Journal: Expert Review of Molecular Diagnostics
Link: PubMed_Link

Title: The methylazoxymethanol acetate (MAM-E17) rat model: molecular and functional effects in the hippocampus
Author: E. Hradetzky et al.
Journal: Neuropsychopharmacology
Link: PubMed_Link

Title: Depression symptom dimensions as predictors of antidepressant treatment outcome: replicable evidence of interest-activity symptoms
Author: R. Uher et al.
Journal: Psychological Medicine
Link: PubMed_Link

Title: Test-retest reliability of evoked BOLD signals from a cognitive-emotive fMRI test battery
Author: M. Plichta et al.
Journal: Neuroimage
Link: PubMed_Link

Title: Selective siRNA-mediated suppression of 5-HT1a autoreceptors evokes strong antidepressant-like effects
Author: A. Bortolozzi et al.
Journal: Molecular Psychiatry
Link: PubMed_Link

Title: Translating cognition from animals to humans
Author: J. F. Keelera et al.
Journal: Biochemical Pharmacology
Link: PubMed_Link

Title: NMDA receptors, cognition and schizophrenia - Testing the validity of the NMDA receptor hypofunction hypothesis
Author: G. Gilmour et al.
Journal: Neuropharmacology
Link: PubMed_Link

Title: Biomarkers predicting treatment outcome in depression: what is clinically significant?
Author: R. Uher et al.
Journal: Pharmacogenomics
Link: PubMed_Link

Title: Spontaneous object recognition and its relevance to schizophrenia: a review of findings from pharmacological, genetic, lesion and developmental rodent models
Author: L. Lyon et al.
Journal: Psychopharmacology
Link: PubMed_Link

Title: The pharmacological sensitivity of a touchscreen-based visual discrimination task in the rat using simple and perceptually challenging stimuli
Author: J. C. Talpos et al.
Journal: Psychopharmacology
Link: PubMed_Link

Title: Delta oscillation and short-term plasticity in the rat medial prefrontal cortex: modelling NMDA hypofunction of schizophrenia
Author: T. Kiss et al.
Journal: The International Journal of Neuropsychopharmacology
Link: Pubmed_Link

Title: Confirmation of fenfluramine effect on 5-HT1B receptor binding of [11C]AZ10419369 using an equilibrium approach
Author:S. J. Finnema et al.
Journal: Journal of Cerebral Blood Flow & Metabolism
Link: Pubmed_Link

Title: Clozapine Reverses Phencyclidine-Induced Desynchronization of Prefrontal Cortex through a 5-HT1A Receptor-Dependent Mechanism
Author: L. Kargieman et al.
Journal: Neuropsychopharmacology
Link: Pubmed_Link

Title: New translational assays for preclinical modelling of cognition in schizophrenia: The touch screen testing method for mice and rats
Author: T. J. Bussey et al.
Journal: Neuropharmacology
Link: Pubmed_Link

Title: 5-HT1A Receptor Agonists Enhance Pyramidal Cell Firing in Prefrontal Cortex Through a Preferential Action on GABA Interneurons
Author: L. Llado-Pelfort et al.
Journal: Cerebral Cortex
Link: Pubmed_Link

Title: A comparison of the effects of ketamine and phencyclidine with other antagonists of the NMDA receptor in rodent assays of attention and working memory
Author: J. Smith et al.
Journal: Psychopharmacology
Link: Pubmed_Link

Title: A within-subject cognitive battery in the rat: differential effects of NMDA receptor antagonists
Author: S. Dix et al.
Journal: Psychopharmacology
Link: Pubmed_Link

Title: Role of thalamic projection in NMDA receptor-induced disruption of cortical slow oscillation and short-term plasticity
Author: T. Kiss et al.
Journal: Frontiers in Psychiatry
Link: Pubmed_Link

Title: Activation of thalamocortical networks by the NMDA receptor antagonist phencyclidine. Reversal by clozapine.
Author: N. Santana et al.
Journal: Biological Psychiatry
Link: Pubmed_Link

Title: Fenfluramine-Induced Serotonin Release Decreases [11C]AZ10419369 Binding to 5-HT1B-Receptors in the Primate Brain
Author: S. J. Finnema et al.
Journal: Synapse
Link: Pubmed_Link

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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